PERBANDINGAN KADAR BILIRUBIN NEONATUS DENGAN DAN TANPA DEFISIENSI GLUCOSE-6-PHOSPHATE DEHYDROGENASE, INFEKSI DAN TIDAK INFEKSI

The Comparison of Bilirubin Level of the Newborn, With and Without Glucose6-Phosphate
Dehydrogenase (G6PD)
Deficiency,
With and
Without Infection

Satrio Wibowo
*, Kamilah Budhi Rahardjani*, Ag. Soemantri*
*Department of Child Health Medical Faculty – Diponegoro University / Dr. Kariadi Hospital Semarang

ABSTRACT

Background : Hyperbilirubinemia is one of the most common problem in newborn and can lead to neural defect. G6PD deficiency is one of the risk factor causing hyperbilirubinemia. It is the most common cause of jaundice and acute hemolytic anemia in South-East Asia. Infection could act as a trigger of hemolysis in G6PD deficient newborn.
Objective : To compare bilirubin level between G6PD deficient and normal neonate, exposed or not exposed by bacterial infection. 

Methods : One hundred and one neonate at the High Risk Neonate Ward in Dr. Kariadi Hospital Semarang have been enrolled in this cross sectional study since January to June 2006. In this study, the subject were divided into 4 groups: (1) G6PD deficient neonate with infection, (2) G6PD deficient neonate without infection, (3) normal neonate with infection, and (4) normal neonate without infection. Variables were compared by using mann-whitney u test or kruskal wallis with SPSS 13.00.
Result : Sixteen (15,8%) neonate were G6PD deficient and 39 (38,6%) neonate were infected. There were no significant difference between bilirubin level of G6PDdeficient newborn and the normal
one

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